New nutritional strategies to modulate postprandial cardiometabolic risk in metabolic disease

Supervisor(s)

Please contact Dr Matthew Campbell to discuss this project further informally.

Project description

Large prospective cohort studies have demonstrated that fasting and postprandial blood lipid levels (lipaemia) are strongly associated with cardiovascular (CVD) risk. Although fasting lipaemia is indicative of the cumulative effects of composite diets and metabolic activity, they do not accurately reflect the impact of individual foods or meals consumed during the day. Humans exist mostly in the non-fasting state, reflecting our habitual physiological status in which sudden influxes of energy and nutrients increase metabolic allostatic loading.

Westernised dietary patterns promote a lipotoxic state involving the activation of various inflammatory and thrombotic pathways which promote vascular dysfunction and play an important role in the pathogenesis of CVD. In every day diet, lipids of various molecular species are incorporated in food products under different physiochemical structures which influence the duration and intensity of postprandial lipaemia. It is important to determine the factors which influence the cardiometabolic impact of food formulations in high-risk populations.

In this research group, we examine how modulating the composition of meals and the matrix of individual foods can optimise targeted nutritional strategies for the clinical and nutritional management of metabolic disease. The student will be part of a multidisciplinary team which has extensive experience in nutritional interventions and the clinical management of metabolic disease. 

Entry requirements

Applications are invited from candidates with or expecting a minimum of a UK upper second class honours degree (2:1 or above or equivalent), and/or a Master's degree in a relevant science subject. Suitable candidates will demonstrate a strong background in basic, human, and/or clinical nutrition and/or food science.

If English is not your first language, you must provide evidence that you meet the University's minimum English Language requirements.

How to apply

Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is 'PhD in New nutritional strategies to modulate postprandial cardiometabolic risk in metabolic disease' as well as Dr Matthew Campbell as your proposed supervisor.
 
We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.

If you require any further information please contact the Graduate School Office e: maps.pgr.admissions@leeds.ac.uk