How do dietary sterols alter cancer cell signalling originating from the plasma membrane?


Dr James L Thorne, Dr Arwen Tyler, Dr Antreas Kalli and Dr Simon Connell. Contact Dr James L Thorne to discuss this project further informally.

Project description

Cell membranes separate the cellular milieu from the external environment and regulate transport in and out of the cell. Membrane biology is a critical variable in chronic diseases associated with diet and nutrition due to the array of dietary factors that alter membrane composition and function.

An emerging research focus is to determine how the array of exogenous dietary factors alter the cell membrane structure and function and how this impacts on chronic disease initiation and progression. A good example of this is how cancer hallmarks such as apoptosis evasion, increased proliferation and metabolic changes have their origins in (de)regulated membrane function. Therapeutic manipulation of the plasma membrane, either pharmacologically or through the diet is an underexploited research area for cancer prevention.

This project will follow on from sucessfull on going research split across biophysics, cancer biology, structural biology and computational biology laboratories. he succssful candidate will develop skills in several areas - full training and support is provided.

Key benefits

  • Multi-discipline training
  • Join a vibrant, successful and growing research group, school and university
  • Be part of a welcoming multi-national research environment

Entry requirements

Applications are invited from candidates with or expecting a minimum of a UK upper second class honours degree (2:1), and/or a Master's degree in biological, physical, computational, mathematical or chemical sciences.

If English is not your first language, you must provide evidence that you meet the University’s minimum English Language requirements.

How to apply

Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is the ‘How do dietary sterols alter cancer cell signalling originating from the plasma membrane?’ as well as Dr James L Thorne as your proposed supervisor.

We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates.  All scholarships will be awarded on the basis of merit.

If you require any further information please contact the Graduate School Office e: