- Number of awards: 1
- Deadline: Ongoing
- Key benefits: You will gain core skills in synthetic organic chemistry of challenging poly-functionalised small molecules together with skills in protein chemistry, biophysical analysis and/or proteomics as you apply your synthesized probes to address particular biological questions.
Contact Dr Mike Webb to discuss this project further informally.
In this project, you will build on our previous work developing stable analogues of phosphohistidine (Org. Biomol. Chem. (2012)10, 4043), dehydroalanine (Chem Commun. (2015) 51 13470) and triazine-containing analogues of phenylalanine (Chem. Eur. J (2015) 21 14376) to generate new probe molecules for chemical proteomics and chemical biology.
Dependent upon the particular target these might have applications in the study of protein phosphorylation by chemical proteomics, in general applications for target identification and protein labelling, or enable us to generate highly functionalised proteins in tandem with our sortase-catalysed methdology (Angew. Chem. Int. Ed. (2012) 51 9377)
Applications are invited from candidates with or expecting a minimum of a UK upper second class honours degree (2:1), and/or a Master's degree in a relevant science subject such as (but not limited to) chemistry or chemical engineering.
How to apply
Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is the ‘Functionalised amino-acid analogues for chemical proteomics’ as well as Dr Mike Webb as your proposed supervisor.
If English is not your first language, you must provide evidence that you meet the University's minimum English Language requirements.
If you require any further information please contact the Graduate School Office e: firstname.lastname@example.org
We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates. All scholarships will be awarded on the basis of merit.