Multifunctional organic-inorganic hybrid nanoparticles


Contact Dr Zhan Yuin Ong to discuss this project further informally.

Project description

Glioblastoma multiforme (GM) is the most aggressive brain cancer with patient survival time typically reported as less than one year following diagnosis. A major challenge in the clinical treatment of GM lies in the poor penetration of chemotherapeutic agents across the highly impermeable blood-brain barrier (BBB) and blood-brain tumour barrier (BBTB). Therefore, the development of novel strategies to increase delivery of anti-cancer agents across the brain and into the tumour is urgently needed.

In this project, the student will build on the BBB and cancer targeting nanosystems developed in our laboratory to develop drug delivery strategies for brain cancer. The student will be trained in a wide range of highly interdisciplinary skills in nanoparticle synthesis and characterization, drug loading and release, as well as biological testing of nanomaterials. In vitro BBB and BBTB models will also be developed for the evaluation of brain targeting efficiency.

Entry requirements

Applications are invited from candidates with, or expecting, a minimum of a UK upper second class honours degree (2:1) in a relevant discipline, a Master's degree in a relevant discipline, or both.

How to apply

Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is 'Development of multifunctional organic-inorganic hybrid nanoparticles for targeted treatment of brain cancer' as well as Dr Zhan Yuin Ong as your proposed supervisor.

If English is not your first language, you must provide evidence that you meet the University’s minimum English Language requirements.

If you require any further information please contact the Graduate School Office

We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates.  All scholarships will be awarded on the basis of merit.