Development of a microfluidic device for biocatalysts


Contact Dr Jung-uk Shim to discuss this project further informally

Project description

This project is to develop a microfluidic system for biocatalyst discovery based on screening libraries of novel enzymes rapidly. This approach is entirely in vitro using microfluidic technology to screen the protein library and molecular biology to generate and characterize the new enzymes. The system will enable one to identify enzymes with new functions and to determine the molecular structure of those molecules. The core technology is structured around microfluidic droplet-manipulating devices where the droplets function as bioreactors.

To accomplish the research goal, microfluidic devices will be built using existing microfluidic technology capable of extremely high-throughput screening of protein mutants, and linkages of each protein molecules and their coding DNAs will be developed to ensure the genotype-phenotype linkage. Beyond the research goal this technology can be further applied to the development of novel catalysts, the study of interactions of proteins-proteins and proteins-small molecules. The PhD candidate will design and fabricate a microfluidic device to manipulate protein molecules and to assess the chemical activity using optical measurements.

Entry requirements

Applications are invited from candidates with, or expecting, a minimum of a UK upper second class honours degree (2:1) in a relevant discipline, a Master's degree in a relevant discipline, or both.

Additional staff contact

Alan Berry (Biology)

How to apply

Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is 'Development of a microfluidic device for extremely high throughput screening of biocatalyst' as well as Dr Jung-uk Shim as your proposed supervisor.

If English is not your first language, you must provide evidence that you meet the University’s minimum English Language requirements.

If you require any further information please contact the Graduate School Office

We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates.  All scholarships will be awarded on the basis of merit