Microfluidic approach to highly sensitive detection of disease state


Contact Dr Jung-uk Shim to discuss this project further informally

Project description

This project is to develop a microfluidic system capable of quantitative detection of target biomarkers at a sensitivity significantly greater than standard ELISA methods. This platform will be developed using a microfluidic technology and the project will demonstrate the utility of its enhanced sensitivity in the area of cancer medicine. Early cancer diagnosis is recognized as a key strategy for improving patient outcomes, however currently available biomarkers are not sufficiently specific to be employed in this context.

Measurement of biomarkers following radical surgery is routinely undertaken in surveillance protocols. We hypothesise that early detection of very small, consistent rises in biomarker levels post surgery may predict disease relapse much earlier than can be achieved using currently available assays, allowing opportunities for better risk stratification, early intervention and an improvement in patient outcomes. The PhD candidate will design and fabricate a microfluidic device to quantify the target biomarkers using an optical measurement.

Entry requirements

Applications are invited from candidates with, or expecting, a minimum of a UK upper second class honours degree (2:1) in a relevant discipline, a Master's degree in a relevant discipline, or both.

Additional staff contact

Alan Anthoney, Naveen Vasudev (Medicine)

How to apply

Formal applications for research degree study should be made online through the university's website. Please state clearly in the research information section that the PhD you wish to be considered for is 'Development of a microfluidic approach for highly sensitive detection of disease state' as well as Dr Jung-uk Shim as your proposed supervisor.

If English is not your first language, you must provide evidence that you meet the University’s minimum English Language requirements.

If you require any further information please contact the Graduate School Office
e: physics.pg.admissions@leeds.ac.uk

We welcome scholarship applications from all suitably-qualified candidates, but UK black and minority ethnic (BME) researchers are currently under-represented in our Postgraduate Research community, and we would therefore particularly encourage applications from UK BME candidates.  All scholarships will be awarded on the basis of merit.