Dr Lorna Dougan
We are developing single molecule manipulation techniques and neutron diffraction to explore the physics of living systems. These powerful techniques are used to study biomolecular self-assembly and the structure and dynamics of molecules in aqueous solutions, in both simple and complex systems. The Dougan Group is based in the School of Physics and Astronomy at the University of Leeds. Its members are also part of the Astbury Centre for Structural Molecular Biology. We gratefully acknowledge funding from the EPSRC
Our group is interested in using novel biophysical approaches to explore the structure and dynamics of molecules in aqueous solutions. The major theme of our multidisciplinary program involves the development of single molecule manipulation techniques as well as structural studies using neutron diffraction and computational modelling. These powerful techniques are used as tools to study biomolecular self-assembly in both simple and complex systems.
Our current areas of interest include:
- The development of instrumentation for the mechanical manipulation of single molecules
- Understanding the action of cryoprotectant molecules
- Hydrogen bonding, percolation and micro-segregation in aqueous solutions
- Protein folding, stability and dynamics under extreme environmental conditions
- The development of enabling tools and technology for synthetic biology
- The design and characterisation of artificial biological levers for molecular motors
- The self-assembly and aggregation of disease relevant peptides and proteins
You can read more about our research on the Dougan Group web site!