Dr Matteo Castronovo
- Position: Lecturer in Biochemistry
- Areas of expertise: biochemistry under nanoscale confinement; DNA and RNA self-assembled nanosystems; biomolecular physics; nanoscience; nanoengineering; nanomedicine; biosensing; multiplexed imaging.
- Email: M.Castronovo@leeds.ac.uk
- Phone: +44(0)113 343 3814
- Location: P2.24b Chemistry
- Website: LinkedIn | Googlescholar | Researchgate | ORCID
Dr Matteo Castronovo joined the School of Food Science and Nutrition at the University of Leeds as Lecturer in Biochemistry in July 2016. Prior to this appointment he headed the Nanobiophysics Laboratory in the Department of Medical and Biological Sciences at the University of Udine, Italy (2013-16). Dr Castronovo also held an appointment at the Aviano National Cancer Institute in Aviano, Italy (2011-13), and a junior faculty position in the Department of Biology at Temple University, Philadelphia, USA (2009-11). He has also held a position of Principal Investigator and Project Coordinator in the Regional Centre for Rare Diseases of the University Hospital of Udine, Italy (Azienda Sanitaria Universitaria Integrata di Udine) since 2016.
- Program Manager of the MSc in Food Biotechnology
- Library Coordinator
Dr Castronovo's research program is in the area of experimental biomolecular nanoscience. A primary goal is to develop innovative approaches to profile protein and nucleic acids in highly heterogeneous tissues, with single-cell resolution. An underlying theme of his research is to join fundamental with applied research. Experimental approaches include the use of atomic force microscopy and nanolithography to study nucleic acid self-assembly on surfaces and in solution, with the goal of developing functional nanodevices.
In his studies, Dr Castronovo has uncovered novel emergent behaviour of nucleic acids in crowded environments, including DNA origami structures. These behaviours reflect structural changes, as well as changes in enzyme diffusion and recognition under conditions of nanoscale confinement and high molecular density. His findings reveal that nucleic acid-nucleic acid and nucleic acid-protein interactions proceed in a qualitatively different manner in dense and ordered nanosystems, compared to their interactions in bulk solution or in the presence of macromolecular crowding agents. These findings suggest that nucleic acid self-assembly can be manipulated to deliberately control the diffusion, recognition, and reactivity of nucleic acid towards enzymes and other ligands. Matteo's long-term vision is that nucleic acid-based biosensors can be developed that can self-adapt to diverse biological microenvironments. In turn, this will allow the development of new bioanalytical approaches that can meet the challenge of the intrinsic heterogeneity of biological tissues.
- PhD in Nanotechnology, University of Trieste, Italy (2004-2008)
- MSc in Theoretical Physics, University of Trieste, Italy (2001-2003)
- BSc in Physical Sciences and Technologies, University of Trieste, Italy (1998-2001)
Research groups and institutes
- Food Chemistry and Biochemistry
- Food Safety, Security and Sustainability
- Obesity, Cancer and Metabolic Disease
- Food Colloids and Soft Matter at Interfaces